Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7743094 | 1.00 | MAPT (0.47) | MAPTSMN1; SMN2HPGDPOLBKMT2A | |
| Acetic Acid SCHEMBL915038 | 0.94 | MAPT (0.48) | MAPTSMN1; SMN2HPGDPOLBKMT2A | |
| Acetic Acid SCHEMBL915039 | 0.94 | MAPT (0.48) | MAPTSMN1; SMN2HPGDPOLBKMT2A | |
| SCHEMBL17044485 | 0.86 | SMN1; SMN2 (0.58) | MAPTSMN1; SMN2HPGDPOLBKMT2A | |
| SCHEMBL17044486 | 0.86 | SMN1; SMN2 (0.58) | MAPTSMN1; SMN2HPGDPOLBKMT2A | |
| Hydrochloric Acid SCHEMBL5703185 | 0.85 | SMN1; SMN2 (0.57) | MAPTSMN1; SMN2HPGDPOLBKMT2A | |
| Hydrochloric Acid SCHEMBL5703189 | 0.85 | SMN1; SMN2 (0.57) | MAPTSMN1; SMN2HPGDPOLBKMT2A | |
| SCHEMBL915041 | 0.83 | MAPT (0.45) | MAPTSMN1; SMN2HPGDPOLBKMT2A | |
| SCHEMBL7743087 | 0.79 | PARP1 (0.48) | MAPTSMN1; SMN2HPGDKMT2ALMNA | |
| SCHEMBL7743089 | 0.79 | PARP1 (0.48) | MAPTSMN1; SMN2HPGDKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001025192-A1 | GUANIDINE DERIVATIVES AND THEIR USE IN THE PRODUCTION OF A MEDICAMENT FOR BLOCKING XANTHINE OXIDASE/DEHYDROGENASE | MELACURE THERAPEUTICS AB (SE) | 2001-04-12 | — | — | WO | claimed |
| US-8410174-B2 | Method for treating arthritis | ANAMAR AB (SE) | 2013-04-02 | — | — | US | disclosed |
| US-8309609-B2 | Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands | ANAMAR AB (SE) | 2012-11-13 | — | — | US | disclosed |