Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR1 | P21462 | 6/20 | 0.37 |
| ▸ | FPR2 | P25090 | 6/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | CPB1 | P15086 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | NLN | Q9BYT8 | 1/20 | 0.33 |
| ▸ | CPA1 | P15085 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7738285 | 0.82 | HRH3 (0.37) | FPR1FPR2CYP19A1 | |
| SCHEMBL7744111 | 0.82 | HRH3 (0.37) | FPR1FPR2CYP19A1 | |
| SCHEMBL7738184 | 0.81 | CYP19A1 (0.41) | FPR1FPR2CYP19A1CPA1FNTA | |
| SCHEMBL8487145 | 0.81 | FPR2 (0.42) | FPR1FPR2PRKAA2 | |
| SCHEMBL7746101 | 0.81 | CYP19A1 (0.43) | FPR1FPR2CYP19A1NLN | |
| SCHEMBL7746078 | 0.80 | KCNJ1 (0.39) | FPR1FPR2CYP19A1DPP4DPP8 | |
| SCHEMBL7744150 | 0.79 | HRH3 (0.37) | CYP19A1 | |
| SCHEMBL7743502 | 0.78 | MAPT (0.43) | CYP19A1 | |
| Trifluoroacetic Acid SCHEMBL7662111 | 0.77 | FNTA (0.39) | CYP19A1CPB2DPP4DPP8DPP9 | |
| SCHEMBL7744222 | 0.76 | CYP11B1 (0.37) | CYP19A1P2RX7FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |