Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 7/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | FNTA | P49354 | 3/20 | 0.48 |
| ▸ | FNTB | P49356 | 3/20 | 0.48 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8483628 | 0.99 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL7738201 | 0.87 | FNTA (0.49) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL694505 | 0.80 | PARP1 (0.45) | — | |
| SCHEMBL7744195 | 0.76 | CYP11B1 (0.55) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL5891899 | 0.76 | CYP11B1 (0.68) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| Hydrochloric Acid SCHEMBL8484200 | 0.75 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL8677989 | 0.75 | CYP11B1 (0.70) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| Hydrochloric Acid SCHEMBL8188315 | 0.75 | CYP11B1 (0.67) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL8482559 | 0.74 | CYP11B1 (0.53) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| Hydrochloric Acid SCHEMBL7744119 | 0.74 | CYP11B1 (0.52) | CYP11B1CYP11B2CYP19A1FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | claimed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | claimed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | claimed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | claimed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |