Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7743703 | 0.84 | BRS3 (0.45) | PARP1ITKLMNASMOLRRK2 | |
| SCHEMBL248215 | 0.82 | PARP1 (0.64) | PARP1ARITKLMNAENPP1 | |
| SCHEMBL30801304 | 0.82 | PARP1 (0.64) | PARP1ARITKLMNAENPP1 | |
| SCHEMBL694632 | 0.81 | LRRK2 (0.39) | PARP1ARITKLMNAKDR | |
| SCHEMBL7743701 | 0.80 | CYP11B1 (0.55) | — | |
| SCHEMBL693552 | 0.80 | PARP1 (0.52) | PARP1ARLMNAENPP1KDM4E | |
| SCHEMBL4488379 | 0.80 | PARP1 (0.52) | PARP1ARITKLMNAENPP1 | |
| SCHEMBL154687 | 0.80 | LMNA (0.49) | PARP1ARLMNAENPP1KDM4E | |
| Hydrochloric Acid SCHEMBL8483628 | 0.79 | CYP11B1 (0.54) | — | |
| SCHEMBL28098683 | 0.76 | CNR1 (0.62) | PARP1ARITKLMNAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421851-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2012-02-29 | — | — | EP | claimed |
| WO-2010124102-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | claimed |