Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.43 |
| ▸ | BRS3 | P32247 | 1/20 | 0.42 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7743707 | 0.81 | CYP1A2 (0.45) | MAPTKDM4ETSHRBRS3 | |
| SCHEMBL7129739 | 0.74 | BRS3 (0.52) | MAPTBRS3RAB9A | |
| SCHEMBL7919393 | 0.73 | BRS3 (0.62) | BRS3 | |
| SCHEMBL10588302 | 0.72 | BRS3 (0.49) | MAPTBRS3RAB9A | |
| SCHEMBL7468902 | 0.72 | HRH3 (0.48) | MAPTBRS3RAB9A | |
| SCHEMBL8498703 | 0.72 | BRS3 (0.49) | MAPTKDM4EKMT2ABRS3RAB9A | |
| SCHEMBL7505077 | 0.72 | LOXL2 (0.49) | MAPTKDM4EBRS3RAB9ACYP2C9 | |
| Hydrochloric Acid SCHEMBL8521500 | 0.72 | BRS3 (0.61) | BRS3 | |
| SCHEMBL8482554 | 0.71 | CYP11B1 (0.57) | KMT2ATDP1GRM2SLC9A1 | |
| SCHEMBL7744107 | 0.71 | TAAR1 (0.47) | KMT2ATSHRBRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | claimed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | claimed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | claimed |
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |