Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | RORC | P51449 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28138782 | 0.90 | TDP1 (0.68) | TDP1CYP3A4ALDH1A1ALOX15GAA | |
| SCHEMBL2833356 | 0.86 | ALDH1A1 (0.57) | TDP1CYP3A4ALDH1A1ALOX15GAA | |
| SCHEMBL13740351 | 0.85 | KMT2A (0.59) | TDP1CYP3A4ALDH1A1ALOX15GAA | |
| SCHEMBL13740073 | 0.85 | KMT2A (0.59) | TDP1CYP3A4ALDH1A1ALOX15GAA | |
| SCHEMBL19490032 | 0.84 | L3MBTL1 (0.59) | TDP1CYP3A4ALDH1A1GAATHRB | |
| SCHEMBL27669863 | 0.83 | ALDH1A1 (0.58) | TDP1CYP3A4ALDH1A1ALOX15GAA | |
| SCHEMBL377824 | 0.81 | ALDH1A1 (0.77) | TDP1CYP3A4ALDH1A1ALOX15GAA | |
| SCHEMBL22890327 | 0.81 | KMT2A (0.64) | TDP1CYP3A4ALDH1A1ALOX15GAA | |
| SCHEMBL346217 | 0.81 | KMT2A (0.64) | TDP1CYP3A4ALDH1A1ALOX15GAA | |
| SCHEMBL11747916 | 0.81 | MAPT (0.51) | TDP1CYP3A4ALDH1A1ALOX15GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6429311-B2 | CHEMICAL INTERMEDIATE FOR HYPOTENSIVE AGENTS, BACTERICIDES, FUNGICIDES, ANTIPYRETICS AND ANTIDEPRESSANTS | SEPRACOR INC. | 2002-08-06 | — | — | US | disclosed |
| US-20010018518-A1 | Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof | GAO YUN (US) | 2001-08-30 | — | — | US | disclosed |
| US-6274383-B1 | REACTING AN AMINO BOUND TO A SOLID SUPPORT WITH AN ISATOIC ANHYDRIDE TO FORM A 2-AMINOBENZAMIDE BOUND TO THE SUPPORT, AND THEN REACTING WITH ALDEHYDE USING A LEWIS ACID CATALYST TO FORM A 2,3-DIHYDRO-4(1H)-QUINAZOLINONE BOUND TO SUPPORT | SEPRACOR INC. | 2001-08-14 | — | — | US | disclosed |
| US-6184377-B1 | ANTIPYRETIC, HYPOTENSIVE, ANTIBACTERIAL, ANTIFUNGAL OR CENTRAL NERVOUS SYSTEM (CNS) ACTIVITY, AS WELL AS THE ABILITY TO INHIBIT ENZYMES | SEPRACOR INC. | 2001-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010018518-A1 | Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof | NQO2, ASNS, AAAS | TDP1 2672/4885CYP3A4 324/4885ALDH1A1 821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.