Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 12/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6035694 | 0.91 | MAP2K1 (0.47) | SMN1; SMN2MAPTNPC1RAB9ATDP1 | |
| SCHEMBL6036200 | 0.89 | KMT2A (0.48) | SMN1; SMN2MAPTNPC1RAB9ATDP1 | |
| SCHEMBL6035841 | 0.88 | PRMT5 (0.46) | SMN1; SMN2HPGDMAPTNPC1RAB9A | |
| SCHEMBL6036426 | 0.88 | MAPT (0.41) | SMN1; SMN2MAPTNPC1RAB9ATDP1 | |
| SCHEMBL6035733 | 0.84 | KMT2A (0.42) | SMN1; SMN2MAPTNPC1RAB9ATDP1 | |
| SCHEMBL6036040 | 0.84 | MAPT (0.56) | SMN1; SMN2MAPTALDH1A1KMT2A | |
| SCHEMBL7743764 | 0.83 | CNR2 (0.44) | SMN1; SMN2HPGDMGLLALDH1A1 | |
| SCHEMBL6036049 | 0.82 | MAPT (0.43) | SMN1; SMN2HPGDMAPTNPC1RAB9A | |
| SCHEMBL6035633 | 0.82 | LMNA (0.49) | SMN1; SMN2MAPTALDH1A1KMT2ADRD3 | |
| SCHEMBL6035383 | 0.82 | LMNA (0.48) | SMN1; SMN2MAPTMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002532414-A | — | — | 2002-10-02 | — | — | JP | claimed |
| EP-1140046-A1 | USE OF A MEK INHIBITOR FOR PREVENTING TRANSPLANT REJECTION | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | claimed |
| EP-1140291-A1 | COMBINATION CHEMOTHERAPY COMPRISING A MITOTIC INHIBITOR AND A MEK INHIBITOR | WARNER-LAMBERT COMPANY LLC (US) | 2001-10-10 | — | — | EP | claimed |
| WO-2000037141-A1 | COMBINATION CHEMOTHERAPY | WARNER-LAMBERT COMPANY (US) | 2000-06-29 | — | — | WO | claimed |
| WO-2000035435-A1 | USE OF A MEK INHIBITOR FOR PREVENTING TRANSPLANT REJECTION | WARNER-LAMBERT COMPANY (US) | 2000-06-22 | — | — | WO | claimed |