Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | SCD | O00767 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566122 | 0.93 | HDAC8 (0.51) | HDAC8PDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL6567304 | 0.92 | HDAC8 (0.56) | HDAC8PDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL8629707 | 0.88 | MCL1 (0.51) | HDAC8PDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL8625477 | 0.88 | MCL1 (0.48) | HDAC8PDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL8629713 | 0.87 | KMT2A (0.53) | HDAC8PDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL8629309 | 0.87 | MEN1 (0.53) | HDAC8PDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL8632085 | 0.86 | HDAC8 (0.50) | HDAC8PDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL6564097 | 0.86 | HDAC8 (0.50) | HDAC8PDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL7746386 | 0.85 | STAT3 (0.52) | MEN1KMT2AHSP90AA1HTTSMN1; SMN2 | |
| SCHEMBL31220380 | 0.85 | CCR5 (0.47) | HDAC8MEN1KMT2AHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1120157-C | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | FIBER GENE CORP (US) | 2003-09-03 | — | — | CN | disclosed |
| US-6329497-B1 | ANTITUMOR AGENTS; VIRICIDES AGAINST HUMAN IMMUNODEFICIENCY VIRUS | THE SCRIPPS RESEARCH INSTITUTE | 2001-12-11 | — | — | US | disclosed |
| EP-0996458-A4 | SANDRAMYCIN ANALOGS | SCRIPPS RESEARCH INST (US) | 2001-05-02 | — | — | EP | disclosed |
| CN-1282737-A | Intermediate product used for preparing substituted quinoline-2-formamide | MOECHST AG (DE) | 2001-02-07 | — | — | CN | disclosed |
| EP-0996458-A1 | SANDRAMYCIN ANALOGS | The Scripps Research Institute (US) | 2000-05-03 | — | — | EP | disclosed |
| WO-1998043663-A1 | SANDRAMYCIN ANALOGS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1998-10-08 | — | — | WO | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| CN-1154365-A | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | HOECHST AG (DE) | 1997-07-16 | — | — | CN | disclosed |