Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | GCK | P35557 | 1/20 | 0.44 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8628366 | 0.92 | MCL1 (0.47) | MCL1MEN1HSP90AA1KMT2ASTAT3 | |
| SCHEMBL7744003 | 0.88 | HDAC8 (0.57) | MEN1HSP90AA1KMT2ASTAT3HTT | |
| SCHEMBL8625477 | 0.86 | MCL1 (0.48) | MCL1MEN1HSP90AA1KMT2ASTAT3 | |
| SCHEMBL8629713 | 0.85 | KMT2A (0.53) | MEN1HSP90AA1KMT2ASTAT3HTT | |
| SCHEMBL8629309 | 0.85 | MEN1 (0.53) | MEN1HSP90AA1KMT2ASTAT3HTT | |
| SCHEMBL6567471 | 0.84 | KMT2A (0.48) | MCL1MEN1HSP90AA1KMT2AL3MBTL1 | |
| SCHEMBL7746386 | 0.83 | STAT3 (0.52) | MEN1HSP90AA1KMT2ASTAT3HTT | |
| SCHEMBL8628704 | 0.82 | KMT2A (0.53) | MEN1HSP90AA1KMT2ASTAT3HTT | |
| SCHEMBL8630299 | 0.82 | PLA2G2D (0.50) | MEN1HSP90AA1KMT2AHDAC8 | |
| SCHEMBL6566122 | 0.82 | HDAC8 (0.51) | MEN1HSP90AA1KMT2AHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |