Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.52 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17625299 | 0.88 | FOLH1 (0.62) | F10CYP19A1KDM4EL3MBTL1FOLH1 | |
| SCHEMBL27490001 | 0.85 | P2RX4 (0.66) | F10KDM4EPLA2G2AP2RX4SMN1; SMN2 | |
| SCHEMBL17625298 | 0.82 | F10 (0.58) | F10KDM4EFOLH1PLA2G2ASMN1; SMN2 | |
| SCHEMBL27361848 | 0.81 | EDNRB (0.54) | CYP19A1KDM4EFOLH1PLA2G2AP2RX4 | |
| SCHEMBL12803744 | 0.80 | ALDH1A1 (0.68) | KDM4EFOLH1P2RX4MEN1KMT2A | |
| SCHEMBL29015820 | 0.79 | FOLH1 (0.49) | F10CYP19A1KDM4EFOLH1PLA2G2A | |
| SCHEMBL25437053 | 0.78 | NPC1 (0.56) | KDM4EALDH1A1 | |
| SCHEMBL23422201 | 0.78 | P2RX4 (0.56) | KDM4EP2RX4SMN1; SMN2MEN1KMT2A | |
| SCHEMBL28208613 | 0.78 | TSHR (0.51) | F10KDM4EL3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL27505541 | 0.78 | F10 (0.54) | F10KDM4EL3MBTL1PLA2G2AP2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1018878-A4 | NOVEL INDOLECARBOXAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODSOF INHIBITING CALPAIN | SMITHKLINE BEECHAM CORP (US) | 2001-01-10 | — | — | EP | disclosed |
| EP-1018878-A1 | NOVEL INDOLECARBOXAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODSOF INHIBITING CALPAIN | SmithKline Beecham Corporation (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998041092-A1 | NOVEL INDOLECARBOXAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODSOF INHIBITING CALPAIN | SMITHKLINE BEECHAM CORPORATION (US) | 1998-09-24 | — | — | WO | disclosed |