Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 9/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | FNTA | P49354 | 2/20 | 0.36 |
| ▸ | FNTB | P49356 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | CPA1 | P15085 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744246 | 0.89 | CYP11B1 (0.40) | CYP19A1HRH3FNTAFNTBCYP11B1 | |
| SCHEMBL7744094 | 0.85 | CYP19A1 (0.40) | CYP19A1HRH3CYP11B1CYP11B2CPA1 | |
| SCHEMBL7738163 | 0.83 | CYP19A1 (0.45) | CYP19A1HRH3CPA1 | |
| SCHEMBL7744172 | 0.75 | CYP19A1 (0.46) | CYP19A1HRH3FNTAFNTBCYP11B1 | |
| SCHEMBL8486902 | 0.74 | HRH3 (0.39) | CYP19A1HRH3CYP11B1CYP11B2IDO1 | |
| SCHEMBL7452182 | 0.70 | OPRD1 (0.50) | CYP19A1HRH3CPA1 | |
| SCHEMBL7738184 | 0.70 | CYP19A1 (0.41) | CYP19A1HRH3FNTAFNTBCYP11B1 | |
| SCHEMBL6923476 | 0.70 | FNTA (0.43) | CYP19A1FNTAFNTBCPA1PGGT1B | |
| SCHEMBL7852349 | 0.70 | CYP19A1 (0.39) | CYP19A1HRH3FNTAFNTBCYP11B1 | |
| SCHEMBL7746101 | 0.69 | CYP19A1 (0.43) | CYP19A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | claimed |
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |