SCHEMBL7744328

SCHEMBL7744328

[O]c1ccccc1-c1ccsc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 4/20 0.52
CYP2B6 P20813 2/20 0.52
CYP2E1 P05181 1/20 0.52
PTPRC P08575 1/20 0.49
MAOB P27338 1/20 0.45
CYP3A4 P08684 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
TDO2 P48775 1/20 0.39
GPR84 Q9NQS5 1/20 0.39
TMIGD3 P0DMS9 1/20 0.38
ADORA2A P29274 1/20 0.38
ADORA1 P30542 1/20 0.38
EDNRA P25101 1/20 0.38
PDK2 Q15119 1/20 0.37
ADRA1D P25100 1/20 0.37
ADRA1A P35348 1/20 0.37
ADRA1B P35368 1/20 0.37
PDGFRB P09619 1/20 0.37
PDGFRA P16234 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4946960 0.84 CYP2A6 (0.64) CYP2A6CYP2B6CYP2E1PTPRCMAOB
SCHEMBL7058734 0.77 CYP2A6 (0.70) CYP2A6CYP2B6CYP2E1PTPRCMAOB
SCHEMBL3181535 0.76 CYP2A6 (0.54) CYP2A6CYP2B6CYP2E1PTPRCMAOB
SCHEMBL27870289 0.76 CYP2A6 (0.67) CYP2A6CYP2B6CYP2E1PTPRCMAOB
SCHEMBL26259994 0.75 CYP2A6 (0.52) CYP2A6CYP2B6CYP2E1PTPRCMAOB
SCHEMBL26259978 0.75 CYP2A6 (0.58) CYP2A6CYP2B6CYP2E1PTPRCMAOB
SCHEMBL6829969 0.74 CYP2A6 (0.52) CYP2A6CYP2B6CYP2E1PTPRCMAOB
SCHEMBL649501 0.74 ALDH1A1 (0.54) CYP2A6CYP2B6CYP2E1PTPRCMAOB
SCHEMBL1310377 0.74 ALDH1A1 (0.54) CYP2A6CYP2B6CYP2E1PTPRCMAOB
SCHEMBL3240839 0.74 CYP2A6 (0.52) CYP2A6CYP2B6CYP2E1PTPRCMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001034198-A2 ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER ELI LILLY AND COMPANY (US) 2001-05-17 WO disclosed