Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 5/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.57 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.55 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.55 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 2/20 | 0.50 |
| ▸ | CNR2 | P34972 | 2/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TASP1 | Q9H6P5 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6107458 | 0.99 | DHODH (0.60) | DHODHNPSR1CACNA1GCACNA1HMALT1 | |
| SCHEMBL7744833 | 0.85 | NPC1 (0.55) | DHODHNPSR1CACNA1GCACNA1HMALT1 | |
| SCHEMBL1899685 | 0.81 | NPSR1 (0.85) | NPSR1MAPTMAPK1GAACRHBP | |
| SCHEMBL1898164 | 0.79 | NPSR1 (0.89) | NPSR1MAPTMAPK1GAACRHBP | |
| SCHEMBL1897764 | 0.79 | GRN (0.72) | NPSR1MAPTMAPK1GAACRHBP | |
| SCHEMBL1897746 | 0.78 | MALT1 (0.77) | DHODHMALT1MAPK9MEN1KMT2A | |
| SCHEMBL16742039 | 0.77 | DHODH (1.00) | DHODHCACNA1GCACNA1H | |
| SCHEMBL1897820 | 0.77 | MALT1 (0.69) | MALT1MAPK9MEN1KMT2A | |
| SCHEMBL146787 | 0.76 | NPSR1 (0.74) | NPSR1MAPTMAPK1GAACRHBP | |
| SCHEMBL7744354 | 0.74 | NPSR1 (0.83) | NPSR1MAPTMAPK1GAACRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | disclosed |