Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | TASP1 | Q9H6P5 | 1/20 | 0.53 |
| ▸ | RPA1 | P27694 | 6/20 | 0.52 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.50 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MARS1 | P56192 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1900846 | 0.86 | NPC1 (0.70) | NPC1TASP1CNR1CNR2MAPT | |
| SCHEMBL6107458 | 0.86 | DHODH (0.60) | TASP1CACNA1GCACNA1HCNR1CNR2 | |
| SCHEMBL7744342 | 0.85 | DHODH (0.62) | TASP1CACNA1GCACNA1HCNR1CNR2 | |
| SCHEMBL1899142 | 0.78 | NPC1 (0.67) | NPC1TASP1CNR1CNR2SMN1; SMN2 | |
| SCHEMBL1897764 | 0.75 | GRN (0.72) | NPC1CNR1CNR2SMN1; SMN2L3MBTL1 | |
| SCHEMBL1898696 | 0.74 | TASP1 (0.81) | NPC1TASP1CNR1CNR2L3MBTL1 | |
| SCHEMBL3064847 | 0.73 | NPC1 (1.00) | NPC1TASP1SMN1; SMN2MAPTCRHBP | |
| SCHEMBL1899805 | 0.72 | NPC1 (0.72) | NPC1TASP1CNR1CNR2SMN1; SMN2 | |
| SCHEMBL1514681 | 0.71 | L3MBTL1 (0.89) | RPA1MALT1SMN1; SMN2PPP1CAL3MBTL1 | |
| SCHEMBL8364830 | 0.70 | MARS1 (0.69) | NPC1RPA1MALT1SMN1; SMN2PPP1CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | disclosed |