Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.48 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744713 | 0.90 | KMT2A (0.62) | MEN1KMT2AAURKARPS6KB1PTGER1 | |
| SCHEMBL1899144 | 0.89 | AURKA (0.56) | MEN1KMT2AAURKARPS6KB1LMNA | |
| SCHEMBL12204899 | 0.89 | AURKA (0.53) | MEN1KMT2AAURKARPS6KB1LMNA | |
| SCHEMBL1902344 | 0.81 | MEN1 (0.78) | MEN1KMT2AAURKARPS6KB1SMN1; SMN2 | |
| SCHEMBL3059005 | 0.81 | SLC22A12 (0.55) | PTGER1 | |
| SCHEMBL1897273 | 0.81 | MEN1 (0.80) | MEN1KMT2AAURKARPS6KB1LMNA | |
| SCHEMBL29699759 | 0.81 | MEN1 (0.79) | MEN1KMT2AAURKARPS6KB1LMNA | |
| SCHEMBL1899756 | 0.80 | MEN1 (1.00) | MEN1KMT2AAURKARPS6KB1LMNA | |
| SCHEMBL7744400 | 0.78 | SLC22A12 (0.51) | PTGER1P2RY14 | |
| SCHEMBL29699835 | 0.75 | CYP3A4 (0.83) | MEN1KMT2AAURKARPS6KB1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | claimed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | claimed |