Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 12/20 | 0.66 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.59 |
| ▸ | DRD4 | P21917 | 3/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.59 |
| ▸ | HRH2 | P25021 | 2/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.59 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.59 |
| ▸ | HTR2B | P41595 | 2/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | DRD2 | P14416 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6695001 | 0.99 | OPRM1 (0.65) | OPRM1OPRL1ADRA2ADRD4SLC6A4 | |
| Hydrochloric Acid SCHEMBL7738855 | 0.98 | OPRM1 (0.64) | OPRM1OPRL1ADRA2ADRD4SLC6A4 | |
| SCHEMBL6662792 | 0.88 | OPRM1 (0.55) | OPRM1OPRL1ADRA2ADRD4SLC6A4 | |
| SCHEMBL6694942 | 0.87 | OPRM1 (0.65) | OPRM1OPRL1ADRA2ADRD4SLC6A4 | |
| SCHEMBL6664282 | 0.81 | OPRM1 (0.48) | OPRM1OPRL1ADRA2ADRD4SLC6A4 | |
| SCHEMBL6701358 | 0.81 | OPRM1 (0.76) | OPRM1OPRL1ADRA2ADRD4SLC6A4 | |
| Desmethylmoramide SCHEMBL2111155 | 0.80 | OPRM1 (0.68) | OPRM1KCNH2MEN1LMNAOPRD1 | |
| SCHEMBL14580936 | 0.80 | OPRM1 (1.00) | OPRM1OPRL1ADRA2ADRD4SLC6A4 | |
| SCHEMBL11611247 | 0.78 | KCNA3 (0.69) | OPRM1OPRL1ADRA2ADRD4SLC6A4 | |
| SCHEMBL7760719 | 0.78 | OPRM1 (0.47) | OPRM1OPRL1ADRA2ADRD4SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811078-A | IN A SOLVENT MIXTURE WITH ETHYL OR ISOPROPYL ALCOHOL AND WATER | ADOLOR CORPORATION (US) | 1998-09-22 | — | — | US | claimed |
| US-5798093-A | ADMINISTERING WITH AN ALCOHOL-WATER MIXTURE | ADOLOR CORPORATION (US) | 1998-08-25 | — | — | US | claimed |
| EP-1011647-A4 | SPRAY FORMULATIONS OF ANTIHYPERALGESIC OPIATES AND METHOD OF TREATING TOPICAL HYPERALGESIC CONDITIONS AND PRURITUS THEREWITH | ADOLOR CORP (US) | 2001-05-16 | — | — | EP | disclosed |
| EP-1011647-A1 | SPRAY FORMULATIONS OF ANTIHYPERALGESIC OPIATES AND METHOD OF TREATING TOPICAL HYPERALGESIC CONDITIONS AND PRURITUS THEREWITH | Adolor Corporation (US) | 2000-06-28 | — | — | EP | disclosed |
| WO-1999003457-A1 | SPRAY FORMULATIONS OF ANTIHYPERALGESIC OPIATES AND METHOD OF TREATING TOPICAL HYPERALGESIC CONDITIONS AND PRURITUS THEREWITH | ADOLOR CORPORATION (US) | 1999-01-28 | — | — | WO | disclosed |
| US-5811078-A | IN A SOLVENT MIXTURE WITH ETHYL OR ISOPROPYL ALCOHOL AND WATER | ADOLOR CORPORATION (US) | 1998-09-22 | — | — | US | disclosed |
| US-5798093-A | ADMINISTERING WITH AN ALCOHOL-WATER MIXTURE | ADOLOR CORPORATION (US) | 1998-08-25 | — | — | US | disclosed |