SCHEMBL7744761

SCHEMBL7744761

O=C(Nc1oc(-c2ccc(-c3cccc([N+](=O)[O-])c3)cc2O)nc1C1=CC=CCC1=S)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPN P05981 1/20 0.46
HDAC2 Q92769 1/20 0.43
ABCG2 Q9UNQ0 1/20 0.39
ALDH1A1 P00352 4/20 0.39
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
MAPT P10636 6/20 0.39
RAC1 P63000 1/20 0.38
ABCB1 P08183 1/20 0.38
ABCC1 P33527 1/20 0.38
FLT1 P17948 1/20 0.38
FLT4 P35916 1/20 0.38
KDR P35968 1/20 0.38
HTT P42858 2/20 0.38
PPARG P37231 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
TDP2 O95551 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7744746 0.91 HPN (0.45) HPNABCG2MAPTRAC1ABCB1
SCHEMBL7744779 0.91 KDR (0.43) HDAC2ALDH1A1MEN1KMT2AMAPT
SCHEMBL7987348 0.88 KDR (0.44) ALDH1A1MEN1KMT2AMAPTFLT1
SCHEMBL7979629 0.86 KDR (0.39) HDAC2ALDH1A1MEN1KMT2AMAPT
SCHEMBL7744773 0.86 HPN (0.41) HPNHDAC2ALDH1A1MEN1KMT2A
SCHEMBL7746563 0.85 HDAC2 (0.53) HPNHDAC2ABCG2ALDH1A1MEN1
SCHEMBL7982878 0.84 MAPT (0.44) HDAC2ABCG2ALDH1A1MEN1KMT2A
SCHEMBL7739003 0.83 HPN (0.44) HPNHDAC2ABCG2ALDH1A1MEN1
SCHEMBL7744196 0.82 KDR (0.54) ALDH1A1MEN1KMT2AMAPTFLT1
SCHEMBL7746621 0.81 HDAC2 (0.49) HPNHDAC2ABCG2ALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1097147-A4 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO INC (US) 2001-11-21 EP claimed
EP-1097147-A1 NOVEL ANGIOGENESIS INHIBITORS Merck & Co., Inc. (US) 2001-05-09 EP claimed
US-6228871-B1 THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY MERCK & CO., INC. 2001-05-08 US claimed
WO-2000002871-A1 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO., INC. (US) 2000-01-20 WO claimed
EP-1097147-A4 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO INC (US) 2001-11-21 EP disclosed
EP-1097147-A1 NOVEL ANGIOGENESIS INHIBITORS Merck & Co., Inc. (US) 2001-05-09 EP disclosed
US-6228871-B1 THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY MERCK & CO., INC. 2001-05-08 US disclosed
WO-2000002871-A1 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO., INC. (US) 2000-01-20 WO disclosed