Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744779 | 0.93 | KDR (0.43) | KDRFLT1FLT4MAPTNPC1 | |
| SCHEMBL7979629 | 0.89 | KDR (0.39) | KDRFLT1FLT4MAPTNPC1 | |
| SCHEMBL7744761 | 0.88 | HPN (0.46) | KDRFLT1FLT4MAPTNPC1 | |
| SCHEMBL7982878 | 0.87 | MAPT (0.44) | KDRFLT1FLT4MAPTNPC1 | |
| SCHEMBL7744196 | 0.85 | KDR (0.54) | KDRFLT1FLT4MAPTNPC1 | |
| SCHEMBL7744059 | 0.83 | KDR (0.53) | KDRFLT1FLT4MAPTNPC1 | |
| SCHEMBL7969457 | 0.82 | KDR (0.42) | KDRFLT1FLT4MAPTNPC1 | |
| SCHEMBL7986670 | 0.80 | KDR (0.50) | KDRFLT1FLT4NPC1RAB9A | |
| SCHEMBL7744056 | 0.80 | HPGD (0.42) | KDRFLT1FLT4MAPTNPC1 | |
| SCHEMBL7985537 | 0.78 | KDR (0.53) | KDRFLT1FLT4MAPTADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235909-B1 | HYDROLYZING AND DECARBOXYLATING 2-HYDROXY-3-CYANO-4-METHOXY PYRIDINE TO GIVE 2,4-DIHYDROXYPYRIDINE, FOLLOWED BY NITRATION TO PREPARE 4-HYDROXY-3-NITRO-2(1H)-PYRIDONE | AVENTIS PHARMACEUTICALS PRODUCTS INC. | 2001-05-22 | — | — | US | disclosed |