Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744779 | 0.96 | KDR (0.43) | KDRFLT1FLT4MAPTKDM4E | |
| SCHEMBL7982878 | 0.91 | MAPT (0.44) | KDRFLT1FLT4MAPTKDM4E | |
| SCHEMBL7987348 | 0.89 | KDR (0.44) | KDRFLT1FLT4MAPTKDM4E | |
| SCHEMBL7980768 | 0.89 | KDR (0.45) | KDRFLT1FLT4MAPTKDM4E | |
| SCHEMBL7744196 | 0.87 | KDR (0.54) | KDRFLT1FLT4MAPTKDM4E | |
| SCHEMBL7744761 | 0.86 | HPN (0.46) | KDRFLT1FLT4MAPTKDM4E | |
| SCHEMBL7986013 | 0.82 | KDR (0.39) | KDRFLT1FLT4MAPTKDM4E | |
| SCHEMBL7744056 | 0.82 | HPGD (0.42) | KDRFLT1FLT4MAPTKDM4E | |
| SCHEMBL7986670 | 0.79 | KDR (0.50) | KDRFLT1FLT4NPC1RAB9A | |
| SCHEMBL7746598 | 0.78 | KDR (0.58) | KDRFLT1FLT4HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |