Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SI | P14410 | 2/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.39 |
| ▸ | HPN | P05981 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7746638 | 0.94 | FLT1 (0.43) | KDRFLT1FLT4KMT2AMEN1 | |
| SCHEMBL7746566 | 0.89 | FLT1 (0.49) | KDRFLT1FLT4KMT2AMEN1 | |
| SCHEMBL7744652 | 0.89 | KDR (0.44) | KDRFLT1FLT4KMT2AMEN1 | |
| SCHEMBL7985540 | 0.88 | KDR (0.47) | AKR1C4AKR1C3AKR1C2AKR1C1KDR | |
| SCHEMBL7746635 | 0.86 | HDAC2 (0.49) | KDRFLT1FLT4KMT2AMEN1 | |
| SCHEMBL7746625 | 0.84 | CA1 (0.46) | AKR1C4AKR1C3AKR1C2AKR1C1KMT2A | |
| SCHEMBL7739025 | 0.84 | FLT1 (0.42) | KDRFLT1FLT4KMT2AMEN1 | |
| SCHEMBL7744757 | 0.83 | MAPT (0.45) | KMT2AMEN1MAPTRAB9AALDH1A1 | |
| SCHEMBL7744065 | 0.83 | KDR (0.54) | KDRFLT1FLT4MAPTHPN | |
| SCHEMBL7746601 | 0.83 | KDR (0.53) | KDRFLT1FLT4KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097147-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-1097147-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000002871-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-01-20 | — | — | WO | disclosed |