SCHEMBL7746601

SCHEMBL7746601

O=C(Nc1oc(-c2ccccc2-c2cccc(O)c2)nc1-c1ccccc1)c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 5/20 0.53
FLT1 P17948 1/20 0.53
FLT4 P35916 1/20 0.53
FABP4 P15090 1/20 0.44
ABCG2 Q9UNQ0 1/20 0.44
SMN1; SMN2 Q16637 5/20 0.42
GAA P10253 1/20 0.42
ALDH1A1 P00352 3/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
HPGD P15428 1/20 0.41
TSHR P16473 1/20 0.41
KMT2A Q03164 3/20 0.41
KDM4E B2RXH2 3/20 0.41
MEN1 O00255 2/20 0.41
POLB P06746 1/20 0.41
ADORA1 P30542 2/20 0.40
LMNA P02545 2/20 0.40
HDAC6 Q9UBN7 1/20 0.40
SERPINE1 P05121 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7985540 0.94 KDR (0.47) KDRFLT1FLT4SMN1; SMN2ALDH1A1
SCHEMBL7744087 0.92 KDR (0.46) KDRFLT1FLT4ABCG2ALDH1A1
SCHEMBL7744061 0.92 KDR (0.50) KDRFLT1FLT4ABCG2NPC1
SCHEMBL7744170 0.91 F2 (0.45) KDRFLT1FLT4SMN1; SMN2GAA
SCHEMBL7746655 0.91 KDR (0.43) KDRFLT1FLT4FABP4ABCG2
SCHEMBL7739071 0.91 KDR (0.43) KDRFLT1FLT4FABP4ABCG2
SCHEMBL7746570 0.90 KDR (0.49) KDRFLT1FLT4FABP4ABCG2
SCHEMBL7738996 0.89 KDR (0.52) KDRFLT1FLT4FABP4SMN1; SMN2
SCHEMBL7744781 0.89 ADCY1 (0.47) KDRFLT1FLT4ABCG2SMN1; SMN2
SCHEMBL7744668 0.87 KDR (0.69) KDRFLT1FLT4FABP4SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1097147-A4 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO INC (US) 2001-11-21 EP claimed
EP-1097147-A1 NOVEL ANGIOGENESIS INHIBITORS Merck & Co., Inc. (US) 2001-05-09 EP claimed
WO-2000002871-A1 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO., INC. (US) 2000-01-20 WO claimed
EP-1097147-A4 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO INC (US) 2001-11-21 EP disclosed
EP-1097147-A1 NOVEL ANGIOGENESIS INHIBITORS Merck & Co., Inc. (US) 2001-05-09 EP disclosed
US-6228871-B1 THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY MERCK & CO., INC. 2001-05-08 US disclosed
WO-2000002871-A1 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO., INC. (US) 2000-01-20 WO disclosed