Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.45 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.43 |
| ▸ | APLNR | P35414 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7746601 | 0.94 | KDR (0.53) | KDRFLT1FLT4MEN1KMT2A | |
| SCHEMBL7744061 | 0.92 | KDR (0.50) | KDRFLT1FLT4SERPINE1AKR1C4 | |
| SCHEMBL7739071 | 0.89 | KDR (0.43) | KDRFLT1FLT4MEN1KMT2A | |
| SCHEMBL7746655 | 0.89 | KDR (0.43) | KDRFLT1FLT4MEN1KMT2A | |
| SCHEMBL7744809 | 0.88 | AKR1C4 (0.41) | KDRFLT1FLT4MEN1KMT2A | |
| SCHEMBL7744087 | 0.88 | KDR (0.46) | KDRFLT1FLT4MEN1KMT2A | |
| SCHEMBL7739089 | 0.88 | KDR (0.60) | KDRFLT1FLT4KDM4ESMN1; SMN2 | |
| SCHEMBL7744170 | 0.85 | F2 (0.45) | KDRFLT1FLT4KDM4ESMN1; SMN2 | |
| SCHEMBL7985537 | 0.85 | KDR (0.53) | KDRFLT1FLT4MEN1KMT2A | |
| SCHEMBL7746570 | 0.84 | KDR (0.49) | KDRFLT1FLT4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | disclosed |