Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 5/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.33 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.33 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
| ▸ | GRM8 | O00222 | 1/20 | 0.33 |
| ▸ | GRM6 | O15303 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GSR | P00390 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL8453423 | 0.91 | GRIK1 (0.32) | GRIK1GRIK2SLC1A1GRM1GRM2 | |
| SCHEMBL4030392 | 0.89 | GABRR1 (0.32) | KMT2A | |
| SCHEMBL4553554 | 0.89 | GABRR1 (0.32) | KMT2A | |
| SCHEMBL5144359 | 0.89 | GABRR1 (0.32) | KMT2A | |
| Aspartic Acid SCHEMBL8446543 | 0.85 | GRIK1 (0.39) | GRIK1GRIK2SLC1A1GRM1GRM2 | |
| Aspartic Acid SCHEMBL8450827 | 0.85 | GRIK1 (0.33) | GRIK1GRIK2SLC1A1GRM1GRM2 | |
| SCHEMBL8364636 | 0.79 | SMN1; SMN2 (0.30) | — | |
| Aspartic Acid SCHEMBL7747010 | 0.79 | GRIK1 (0.39) | GRIK1GRIK2SLC1A1GRM1GRM2 | |
| SCHEMBL8424379 | 0.79 | CAMK2A (0.33) | — | |
| SCHEMBL1880686 | 0.79 | CAMK2A (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184336-B1 | USEFUL AS CHELANTS IN WATER TREATMENT | NALCO CHEMICAL COMPANY | 2001-02-06 | — | — | US | disclosed |
| US-5929198-A | HIGH MOLECULAR WEIGHT POLYMERS MODIFIED WITH N-DERIVATIZED COMPOUNDS | NALCO CHEMICAL COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| US-5876623-A | ANTIDEPOSIT AGENT | NALCO CHEMICAL COMPANY (US) | 1999-03-02 | — | — | US | disclosed |
| EP-0832851-A1 | Biodegradable poly (amino acids), derivatized amino acid polymers and methods for making the same | Nalco Chemical Company (US) | 1998-04-01 | — | — | EP | disclosed |
| EP-0831066-A1 | Biodegradable Aspartic acid polymers for preventing scale formation in boilers | NALCO CHEMICAL COMPANY (US) | 1998-03-25 | — | — | EP | disclosed |