Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 2/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | NOS2 | P35228 | 2/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8420549 | 0.91 | TSHR (0.33) | — | |
| Aspartic Acid SCHEMBL7744939 | 0.85 | GRIK1 (0.35) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Aspartic Acid SCHEMBL8453423 | 0.80 | GRIK1 (0.32) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Aspartic Acid SCHEMBL8446543 | 0.78 | GRIK1 (0.39) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| SCHEMBL5144359 | 0.75 | GABRR1 (0.32) | — | |
| SCHEMBL4553554 | 0.75 | GABRR1 (0.32) | — | |
| SCHEMBL8096749 | 0.75 | CA2 (0.39) | — | |
| SCHEMBL4030392 | 0.75 | GABRR1 (0.32) | — | |
| SCHEMBL29896405 | 0.73 | CA2 (0.38) | — | |
| SCHEMBL29896413 | 0.73 | CA2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5876623-A | ANTIDEPOSIT AGENT | NALCO CHEMICAL COMPANY (US) | 1999-03-02 | — | — | US | disclosed |
| EP-0831066-A1 | Biodegradable Aspartic acid polymers for preventing scale formation in boilers | NALCO CHEMICAL COMPANY (US) | 1998-03-25 | — | — | EP | disclosed |