Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 3/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | OXER1 | Q8TDS5 | 4/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | F7 | P08709 | 3/20 | 0.38 |
| ▸ | F3 | P13726 | 3/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4582612 | 0.92 | KEAP1 (0.46) | HCAR2KEAP1NFE2L2PPARAPTGS1 | |
| SCHEMBL4941624 | 0.92 | MAPT (0.50) | HCAR2KEAP1NFE2L2PPARAPTGS1 | |
| SCHEMBL4581859 | 0.92 | MAPT (0.50) | HCAR2KEAP1NFE2L2PPARAPTGS1 | |
| SCHEMBL4938743 | 0.92 | KEAP1 (0.46) | HCAR2KEAP1NFE2L2PPARAPTGS1 | |
| SCHEMBL4940202 | 0.90 | ALDH1A1 (0.49) | HCAR2KEAP1NFE2L2PPARAPTGS1 | |
| SCHEMBL4582361 | 0.90 | ALDH1A1 (0.49) | HCAR2KEAP1NFE2L2PPARAPTGS1 | |
| SCHEMBL18785353 | 0.87 | ALDH1A1 (0.53) | PPARAPTGS1ALDH1A1MAPTOXER1 | |
| SCHEMBL690239 | 0.86 | — | — | |
| SCHEMBL690353 | 0.86 | — | — | |
| SCHEMBL5834728 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015553-A4 | RECOMBINANT bHLH-PAS/JHR POLYPEPTIDE AND ITS USE TO SCREEN POTENTIAL INSECTICIDES | AMERICAN CYANAMID CO (US) | 2001-09-26 | — | — | EP | disclosed |
| EP-1015553-A1 | RECOMBINANT bHLH-PAS/JHR POLYPEPTIDE AND ITS USE TO SCREEN POTENTIAL INSECTICIDES | American Cyanamid Company (US) | 2000-07-05 | — | — | EP | disclosed |
| WO-1998046724-A1 | RECOMBINANT bHLH-PAS/JHR POLYPEPTIDE AND ITS USE TO SCREEN POTENTIAL INSECTICIDES | AMERICAM CYANAMID COMPANY (US) | 1998-10-22 | — | — | WO | disclosed |