Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3412438 | 0.87 | MAPK8 (0.46) | KDM4EHIF1ASTAT3ALDH1A1MAPT | |
| SCHEMBL1899541 | 0.85 | CYP1A2 (0.48) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5493286 | 0.80 | KDM4E (0.41) | KDM4EHIF1ASTAT3ALDH1A1MAPT | |
| SCHEMBL904609 | 0.79 | CYP1A2 (0.48) | KDM4ERNASEH1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL998544 | 0.79 | KDM4E (0.45) | KDM4EHIF1ASTAT3ALDH1A1MAPT | |
| SCHEMBL998168 | 0.79 | KDM4E (0.45) | KDM4EHIF1ASTAT3ALDH1A1MAPT | |
| SCHEMBL998780 | 0.77 | KDM4E (0.43) | KDM4EHIF1ASTAT3MAPTCYP1A2 | |
| SCHEMBL997498 | 0.77 | KDM4E (0.43) | KDM4EHIF1ASTAT3ALDH1A1MAPT | |
| SCHEMBL28503864 | 0.77 | KDM4E (0.57) | KDM4EHIF1ASTAT3CDC7ALDH1A1 | |
| SCHEMBL2599805 | 0.76 | KDM4E (0.60) | KDM4EHIF1ASTAT3CDC7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | disclosed |