Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7745040 | 0.87 | KDM4E (0.55) | KDM4EHIF1ASTAT3ALDH1A1NPC1 | |
| SCHEMBL998544 | 0.74 | KDM4E (0.45) | KDM4EHIF1ASTAT3ALDH1A1GAA | |
| SCHEMBL998168 | 0.74 | KDM4E (0.45) | MAPK8KDM4EHIF1ASTAT3LRRK2 | |
| SCHEMBL998780 | 0.73 | KDM4E (0.43) | KDM4EHIF1ASTAT3MEN1KMT2A | |
| SCHEMBL997498 | 0.73 | KDM4E (0.43) | KDM4EHIF1ASTAT3ALDH1A1L3MBTL1 | |
| SCHEMBL1899541 | 0.72 | CYP1A2 (0.48) | KDM4EALDH1A1NPC1CYP1A2CYP3A4 | |
| SCHEMBL2599805 | 0.72 | KDM4E (0.60) | KDM4EHIF1ASTAT3LRRK2KMT2A | |
| SCHEMBL4958867 | 0.71 | PTGS2 (0.46) | MAPK8KDM4EHIF1ASTAT3AR | |
| SCHEMBL5493286 | 0.71 | KDM4E (0.41) | KDM4EHIF1ASTAT3ALDH1A1GAA | |
| SCHEMBL7737920 | 0.71 | KDM4E (0.59) | KDM4EHIF1ASTAT3LRRK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257340-A2 | COMPOUNDS FOR TREATING MUSCULAR DYSTROPHY | BioMarin IGA Limited (BS) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009121623-A2 | COMPOUNDS FOR TREATING MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2009-10-08 | — | — | WO | disclosed |