Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL998168 | 0.89 | KDM4E (0.45) | KDM4ESTAT3HIF1AALDH1A1HSD17B10 | |
| SCHEMBL998544 | 0.89 | KDM4E (0.45) | KDM4ESTAT3HIF1AALDH1A1HTT | |
| SCHEMBL998780 | 0.85 | KDM4E (0.43) | KDM4ESTAT3HIF1AHSD17B10LMNA | |
| SCHEMBL7745040 | 0.77 | KDM4E (0.55) | KDM4ESTAT3HIF1AALDH1A1MAPT | |
| SCHEMBL4791540 | 0.76 | KDM4E (0.59) | KDM4ESTAT3HIF1AHSD17B10LMNA | |
| SCHEMBL5023203 | 0.75 | TBXA2R (0.45) | HIF1AHTTLMNAP2RX7NPSR1 | |
| SCHEMBL997788 | 0.75 | ALPL (0.39) | KDM4ESTAT3HIF1AALDH1A1HTT | |
| SCHEMBL2862825 | 0.74 | KDM4E (0.59) | KDM4ESTAT3HIF1AHSD17B10LMNA | |
| SCHEMBL3412438 | 0.73 | MAPK8 (0.46) | KDM4ESTAT3HIF1AALDH1A1MAPT | |
| SCHEMBL2071431 | 0.70 | KDM4E (0.55) | KDM4ESTAT3HIF1AHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786424-A2 | LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT | The University of Kansas (US) | 2007-05-23 | — | — | EP | claimed |
| WO-2006023704-A2 | LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT | UNIVERSITY OF KANSAS (US) | 2006-03-02 | — | — | WO | claimed |
| EP-2451783-A2 | LONIDAMINE ANALOGUES FOR FERTILITY MANAGEMENT | University Of Kansas (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005759-A2 | LONIDAMINE ANALOGUES FOR FERTILITY MANAGEMENT | UNIVERSITY OF KANSAS (US) | 2011-01-13 | — | — | WO | disclosed |