SCHEMBL7745979

SCHEMBL7745979

NC(=O)c1[nH]c2ccccc2c1Cc1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.57
ALDH1A1 P00352 4/20 0.57
MAP2 P11137 1/20 0.56
FOLH1 Q04609 1/20 0.50
HPGD P15428 2/20 0.48
MEN1 O00255 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2C9 P11712 1/20 0.48
TSHR P16473 1/20 0.48
CYP2C19 P33261 1/20 0.48
MTNR1A P48039 1/20 0.48
MTNR1B P49286 1/20 0.48
KMT2A Q03164 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
SIRT2 Q8IXJ6 1/20 0.47
SIRT1 Q96EB6 1/20 0.47
GAA P10253 2/20 0.46
EGFR P00533 2/20 0.46
SRC P12931 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6756295 0.87 KDM4E (0.65) KDM4EALDH1A1FOLH1HPGDMEN1
SCHEMBL7563569 0.85 GAA (0.61) KDM4EALDH1A1FOLH1HPGDMEN1
SCHEMBL4262908 0.83 KDM4E (0.62) KDM4EALDH1A1MAP2FOLH1GAA
SCHEMBL5279031 0.82 MAP2 (0.57) KDM4EALDH1A1MAP2FOLH1HPGD
SCHEMBL28746390 0.81 MCL1 (0.57) KDM4EALDH1A1MAP2FOLH1EGFR
SCHEMBL5495499 0.79 HTR6 (0.66) KDM4EALDH1A1MAP2FOLH1GAA
SCHEMBL7671532 0.79 HTR6 (0.68) KDM4EALDH1A1HPGDTSHRGAA
SCHEMBL13701155 0.78 KDM4E (0.71) KDM4EALDH1A1FOLH1HPGDMEN1
SCHEMBL631701 0.78 MAP2 (0.53) KDM4EALDH1A1MAP2FOLH1HPGD
SCHEMBL2983431 0.77 MAP2 (0.51) KDM4EALDH1A1MAP2FOLH1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1018878-A4 NOVEL INDOLECARBOXAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODSOF INHIBITING CALPAIN SMITHKLINE BEECHAM CORP (US) 2001-01-10 EP claimed
EP-1018878-A1 NOVEL INDOLECARBOXAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODSOF INHIBITING CALPAIN SmithKline Beecham Corporation (US) 2000-07-19 EP claimed
WO-1998041092-A1 NOVEL INDOLECARBOXAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODSOF INHIBITING CALPAIN SMITHKLINE BEECHAM CORPORATION (US) 1998-09-24 WO claimed
US-6214856-B1 TREATING NEURODEGENERATIVE DISORDERS, E.G., ALZHEIMER'S DISEASE, STROKES, TRAUMATIC BRAIN INJURY; ANTIISCHEMIC AGENTS; MUSCULAR DYSTROPHY; ALSO CATARACTS; PLATELET AGGREGATION SMITHKLINE BEECHAM CORPORATION 2001-04-10 US disclosed