Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2 | P11137 | 2/20 | 0.57 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5495499 | 0.87 | HTR6 (0.66) | MAP2FOLH1KDM4EALDH1A1HTR6 | |
| SCHEMBL2002751 | 0.86 | FOLH1 (0.71) | FOLH1KDM4EALDH1A1MCL1HPGD | |
| SCHEMBL28746390 | 0.85 | MCL1 (0.57) | MAP2FOLH1KDM4EALDH1A1HTR6 | |
| SCHEMBL4262908 | 0.83 | KDM4E (0.62) | MAP2FOLH1KDM4EALDH1A1EGFR | |
| SCHEMBL7745979 | 0.82 | KDM4E (0.57) | MAP2FOLH1KDM4EALDH1A1EGFR | |
| SCHEMBL631701 | 0.82 | MAP2 (0.53) | MAP2FOLH1KDM4EALDH1A1HTR6 | |
| SCHEMBL2983431 | 0.81 | MAP2 (0.51) | MAP2FOLH1KDM4EALDH1A1HTR6 | |
| SCHEMBL9266502 | 0.80 | MAP2 (0.50) | MAP2FOLH1KDM4EALDH1A1HTR6 | |
| SCHEMBL4033965 | 0.80 | MAP2 (0.50) | MAP2FOLH1KDM4EALDH1A1HTR6 | |
| SCHEMBL6430294 | 0.79 | ALDH1A1 (0.57) | MAP2FOLH1KDM4EALDH1A1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006055-B | 3-substituted-5-and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase ie | AVENTIS PHARMA INC | 2011-06-22 | — | — | CN | disclosed |
| CN-101006055-A | 3-substituted-5- and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase iepsilon | AVENTIS PHARMA INC (US) | 2007-07-25 | — | — | CN | disclosed |
| EP-1794122-A1 | 3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I | Aventis Pharmaceuticals, Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006023467-A1 | 3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE Iϵ | AVENTIS PHARMACEUTICALS INC. (US) | 2006-03-02 | — | — | WO | disclosed |