Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 3/20 | 0.44 |
| ▸ | MMP3 | P08254 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2616891 | 0.81 | ACE (0.50) | ACEALDH1A1LMNACHEK1JAK2 | |
| SCHEMBL32676972 | 0.81 | ACE (0.54) | ACEALDH1A1LMNACHEK1JAK2 | |
| SCHEMBL30940344 | 0.81 | ACE (0.50) | ACEALDH1A1LMNACHEK1JAK2 | |
| SCHEMBL13971489 | 0.81 | ACE (0.54) | ACEALDH1A1LMNACHEK1JAK2 | |
| SCHEMBL3840630 | 0.81 | ACE (0.61) | ACEALDH1A1LMNACHEK1JAK2 | |
| SCHEMBL3154327 | 0.81 | ACE (0.54) | ACEALDH1A1LMNACHEK1JAK2 | |
| SCHEMBL2092090 | 0.81 | ACE (0.54) | ACEALDH1A1LMNACHEK1JAK2 | |
| SCHEMBL8908771 | 0.81 | ACE (0.61) | ACEALDH1A1LMNACHEK1JAK2 | |
| SCHEMBL4573235 | 0.81 | ACE (0.61) | ACEALDH1A1LMNACHEK1JAK2 | |
| SCHEMBL14337677 | 0.80 | CHEK1 (0.58) | ACEALDH1A1LMNACHEK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |