Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908771 | 1.00 | ACE (0.61) | ACEPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL3840630 | 1.00 | ACE (0.61) | ACEPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL11350319 | 0.88 | ACE (0.59) | ACEPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL28561301 | 0.86 | ACE (0.48) | ACEPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL4113622 | 0.86 | ACE (0.66) | ACEPOLBTDP1L3MBTL1CHEK1 | |
| SCHEMBL8620971 | 0.85 | NR1D1 (0.47) | ACEPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL4627296 | 0.85 | ACE (0.60) | ACEPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL5720519 | 0.85 | ACE (0.60) | ACEPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL8495772 | 0.85 | LMNA (0.61) | ACEPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL14397408 | 0.83 | ACE (0.59) | ACEPOLBTDP1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024019562-A1 | HETEROBICYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 바오밥에이바이오 | 2024-01-25 | — | — | WO | disclosed |
| WO-2008100618-A2 | CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. (US) | 2008-08-21 | — | — | WO | disclosed |
| WO-2007011290-A1 | Bronchorelaxing agents based on indol- and isoquinoline derivatives | RESPIRATORIUS AB (SE) | 2007-01-25 | — | — | WO | disclosed |
| US-5688946-A | DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | HOFFMANN LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0696593-A2 | Inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-02-14 | — | — | EP | disclosed |
| EP-0675112-A1 | Imidazole-containing inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-10-04 | — | — | EP | disclosed |
| EP-0618221-A2 | Heterocyclic inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-10-05 | — | — | EP | disclosed |