Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.54 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | GALR3 | O60755 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17815800 | 0.86 | AURKA (0.56) | CNR1KDM4CRAB9AGALR3HDAC6 | |
| SCHEMBL17802580 | 0.86 | KDM4C (0.55) | CNR1KDM4CRAB9AGALR3ALDH1A1 | |
| SCHEMBL5233252 | 0.82 | HTT (0.58) | KDM4CRAB9AGALR3ALDH1A1AURKA | |
| SCHEMBL29634669 | 0.82 | HTT (0.58) | KDM4CRAB9AGALR3ALDH1A1AURKA | |
| SCHEMBL7746181 | 0.78 | BDKRB1 (0.48) | CNR1RAB9ACA1CA2NPC1 | |
| SCHEMBL10873653 | 0.77 | KDM4C (0.60) | CNR1KDM4CRAB9AGALR3CNR2 | |
| SCHEMBL30983851 | 0.77 | KDM4C (0.72) | KDM4CRAB9AGALR3ALDH1A1 | |
| SCHEMBL783719 | 0.77 | KDM4C (0.72) | KDM4CRAB9AGALR3ALDH1A1 | |
| SCHEMBL12392383 | 0.76 | CCNC (0.53) | CNR1RAB9ACA1CA2NPC1 | |
| SCHEMBL11827284 | 0.76 | STAT1 (0.62) | KDM4CRAB9AGALR3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686631-B1 | Pyrimidine derivatives and pharmaceutical compositions | KUREHA CHEMICAL IND CO LTD (JP) | 2001-01-17 | — | — | EP | disclosed |
| US-5585381-A | HYPOTENSIVE AGENT AND ALSO TREATING KIDNEY RENAL DISEASE | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1996-12-17 | — | — | US | disclosed |
| EP-0686631-A1 | Pyrimidine derivatives and pharmaceutical composition | Kureha Chemical Industry Co., Ltd. (JP) | 1995-12-13 | — | — | EP | disclosed |