SCHEMBL7746181

SCHEMBL7746181

CCCCC(=O)Nc1c(Cl)ncnc1NCc1ccc(C(=O)OC)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BDKRB1 P46663 2/20 0.48
CNR1 P21554 1/20 0.48
RAB9A P51151 3/20 0.42
NPC1 O15118 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
ALDH1A1 P00352 2/20 0.42
HPGD P15428 2/20 0.42
CA1 P00915 3/20 0.41
CA2 P00918 3/20 0.41
HDAC3 O15379 2/20 0.40
HDAC4 P56524 2/20 0.40
HDAC1 Q13547 2/20 0.40
HDAC7 Q8WUI4 2/20 0.40
HDAC2 Q92769 2/20 0.40
HDAC10 Q969S8 2/20 0.40
HDAC11 Q96DB2 2/20 0.40
HDAC8 Q9BY41 2/20 0.40
HDAC6 Q9UBN7 2/20 0.40
HDAC9 Q9UKV0 2/20 0.40
HDAC5 Q9UQL6 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7750846 0.88 HPGD (0.47) BDKRB1CNR1NPC1SMN1; SMN2ALDH1A1
SCHEMBL7753157 0.88 BDKRB1 (0.53) BDKRB1CNR1RAB9ANPC1SMN1; SMN2
SCHEMBL7753170 0.88 GSK3B (0.48) BDKRB1CNR1SMN1; SMN2ALDH1A1HPGD
SCHEMBL7746182 0.83 BDKRB1 (0.49) BDKRB1CNR1RAB9ANPC1SMN1; SMN2
SCHEMBL7746195 0.80 BDKRB1 (0.46) BDKRB1CNR1RAB9ANPC1SMN1; SMN2
SCHEMBL7752026 0.79 SMN1; SMN2 (0.47) BDKRB1CNR1RAB9ANPC1SMN1; SMN2
SCHEMBL7752068 0.79 BDKRB1 (0.44) BDKRB1CNR1SMN1; SMN2ALDH1A1HPGD
SCHEMBL7751822 0.78 BDKRB1 (0.46) BDKRB1ALDH1A1HPGDHDAC3HDAC4
SCHEMBL7746233 0.78 CNR1 (0.54) CNR1RAB9ANPC1ALDH1A1CA1
SCHEMBL7750841 0.77 EGFR (0.52) BDKRB1NPC1SMN1; SMN2ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-8048672-A None JP disclosed
EP-0686631-B1 Pyrimidine derivatives and pharmaceutical compositions KUREHA CHEMICAL IND CO LTD (JP) 2001-01-17 EP disclosed
US-5585381-A HYPOTENSIVE AGENT AND ALSO TREATING KIDNEY RENAL DISEASE KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) 1996-12-17 US disclosed
JP-H0848672-A PYRIMIDINE DERIVATIVE KUREHA CHEM IND CO LTD 1996-02-20 JP disclosed
EP-0686631-A1 Pyrimidine derivatives and pharmaceutical composition Kureha Chemical Industry Co., Ltd. (JP) 1995-12-13 EP disclosed