Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | MTOR | P42345 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083747 | 0.89 | ELANE (0.51) | ADORA1ADORA3ADORA2AADORA2BPIK3CA | |
| SCHEMBL7752203 | 0.82 | ADORA1 (0.47) | ADORA1ADORA3ADORA2AADORA2BPIK3CA | |
| SCHEMBL4084126 | 0.77 | MAT2A (0.47) | KMT2AELANETSHRALDH1A1USP2 | |
| SCHEMBL4078297 | 0.77 | MAT2A (0.47) | KMT2AELANETSHRALDH1A1USP2 | |
| SCHEMBL7751006 | 0.76 | MAT2A (0.46) | KMT2AELANETSHRNUDT1TP53 | |
| SCHEMBL5189246 | 0.74 | ADORA1 (0.47) | ADORA1ADORA3ADORA2AADORA2BPIK3CA | |
| SCHEMBL8355465 | 0.74 | ADORA1 (0.47) | ADORA1ADORA3ADORA2AADORA2BPIK3CA | |
| SCHEMBL2825572 | 0.74 | ADORA1 (0.47) | ADORA1ADORA3ADORA2AADORA2BPIK3CA | |
| SCHEMBL4077312 | 0.74 | ADORA1 (0.47) | ADORA1ADORA3ADORA2AADORA2BPIK3CA | |
| SCHEMBL7749780 | 0.73 | MAT2A (0.47) | KMT2AELANETSHRNUDT1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6680324-B2 | 4-AMINO-6-PHENYL-PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES | OSI PHARMACEUTICALS, INC. | 2004-01-20 | — | — | US | disclosed |