SCHEMBL7746486

SCHEMBL7746486

C=COCCOc1cccc(C(F)(F)F)c1

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.57
MAOB P27338 1/20 0.49
AOC3 Q16853 1/20 0.49
KDM4E B2RXH2 4/20 0.48
ALOX15 P16050 1/20 0.48
LTA4H P09960 1/20 0.45
ALDH1A1 P00352 3/20 0.44
HRH3 Q9Y5N1 1/20 0.44
MRGPRX4 Q96LA9 1/20 0.44
LMNA P02545 1/20 0.44
PKM P14618 1/20 0.44
HSD17B10 Q99714 1/20 0.44
POLB P06746 1/20 0.44
MCL1 Q07820 1/20 0.44
GAA P10253 1/20 0.43
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14376401 0.84 L3MBTL1 (0.43) L3MBTL1KDM4EALDH1A1LMNAPOLB
SCHEMBL419321 0.83 MAPK1 (0.44) L3MBTL1KDM4EALDH1A1LMNAPOLB
SCHEMBL24854681 0.83 L3MBTL1 (0.55) L3MBTL1MAOBAOC3KDM4EALOX15
SCHEMBL12409058 0.82 L3MBTL1 (0.66) L3MBTL1MAOBAOC3KDM4EALOX15
SCHEMBL15282329 0.81 MAPK1 (0.43) L3MBTL1KDM4EALDH1A1LMNAPOLB
SCHEMBL31267637 0.81 L3MBTL1 (0.57) L3MBTL1MAOBAOC3KDM4EALOX15
SCHEMBL72484 0.80 L3MBTL1 (0.59) L3MBTL1MAOBAOC3KDM4EALOX15
SCHEMBL3426128 0.80 MAPK1 (0.43) L3MBTL1MAOBKDM4EALDH1A1LMNA
SCHEMBL14589427 0.79 GPR84 (0.39) L3MBTL1KDM4EALOX15
SCHEMBL3163926 0.79 L3MBTL1 (0.61) L3MBTL1MAOBAOC3KDM4EALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6314225-B1 Halogen and perhalo-organo substituted N-phenyl (or biphenyl) maleimide CORNING INCORPORATED 2001-11-06 US disclosed
WO-2001038411-A1 N-HALOGENATED MALEIMIDE COPOLYMERS AND OPTICAL MATERIALS THEREOF CORNING INCORPORATED (US) 2001-05-31 WO disclosed