SCHEMBL7746630

SCHEMBL7746630

CCOC(=O)N(C(C)=O)c1ccc(C=CC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1

nearest known ligand 0.76

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7742464 0.92 BDKRB2 (0.77) BDKRB2
SCHEMBL7742917 0.92 BDKRB2 (0.79) BDKRB2
SCHEMBL8361721 0.92 BDKRB2 (0.81) BDKRB2
SCHEMBL8802731 0.92 BDKRB2 (0.81) BDKRB2
SCHEMBL7748185 0.90 BDKRB2 (0.77) BDKRB2
SCHEMBL6641461 0.88 BDKRB2 (0.87) BDKRB2
SCHEMBL6641454 0.88 BDKRB2 (0.87) BDKRB2
SCHEMBL7748680 0.88 BDKRB2 (0.79) BDKRB2
SCHEMBL8367602 0.88 BDKRB2 (0.76) BDKRB2
SCHEMBL9093951 0.87 BDKRB2 (0.81) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0622361-B1 Heterocyclic compounds as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 2001-10-04 EP disclosed
US-6169095-B1 FOR PREVENTION AND/OR TREATMENT OF BRADYKININ OR ITS ANALOGUES MEDIATED DISEASES IN THE EYE, SUCH AS ALLERGY, INFLAMMATION AND PAIN OF THE EYE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-01-02 US disclosed
US-5563162-A CAN BE ADMINISTERD FOR THE TREATMENT OF ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASES, SHOCK OR PAIN IN ANIMALS AND HUMANS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-10-08 US disclosed
EP-0622361-A1 Heterocyclic compounds as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-11-02 EP disclosed