SCHEMBL8367602

SCHEMBL8367602

CC(=O)N(c1ccccn1)c1ccc(C=CC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1

nearest known ligand 0.76

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7748323 0.94 BDKRB2 (0.79) BDKRB2
SCHEMBL7748680 0.92 BDKRB2 (0.79) BDKRB2
SCHEMBL8361721 0.92 BDKRB2 (0.81) BDKRB2
SCHEMBL8802731 0.92 BDKRB2 (0.81) BDKRB2
SCHEMBL8367811 0.91 BDKRB2 (0.81) BDKRB2
SCHEMBL7748185 0.89 BDKRB2 (0.77) BDKRB2
SCHEMBL7746630 0.88 BDKRB2 (0.76) BDKRB2
SCHEMBL7742464 0.88 BDKRB2 (0.77) BDKRB2
SCHEMBL7747827 0.87 BDKRB2 (0.81) BDKRB2
SCHEMBL7747164 0.87 BDKRB2 (0.81) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5994368-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, ANALGESICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-11-30 US disclosed
EP-0807105-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-11-19 EP disclosed
WO-1996013485-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-05-09 WO disclosed