Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.32 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744409 | 0.82 | ALDH1A1 (0.41) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5311780 | 0.76 | CYP1A2 (0.44) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1901123 | 0.74 | ATM (0.42) | CYP1A2CYP3A4ALDH1A1HPGDPARP1 | |
| SCHEMBL5315808 | 0.71 | CYP1A2 (0.48) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6854925 | 0.71 | GAA (0.51) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1899541 | 0.68 | CYP1A2 (0.48) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5312171 | 0.68 | CYP1A2 (0.44) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL15527879 | 0.67 | SLC16A3 (0.44) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL181369 | 0.66 | MEN1 (0.52) | MEN1KMT2AATML3MBTL1HTR2A | |
| SCHEMBL2328937 | 0.65 | PARP1 (0.47) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | disclosed |