Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | CDC25A | P30304 | 3/20 | 0.45 |
| ▸ | CDC25B | P30305 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3083631 | 0.89 | MAPT (0.59) | MAPTLMNARXFP1POLBCDC25A | |
| SCHEMBL3071327 | 0.83 | LMNA (0.60) | MAPTLMNARXFP1POLBCDC25A | |
| SCHEMBL3074301 | 0.82 | TP53 (0.53) | MAPTLMNARXFP1POLBCDC25A | |
| SCHEMBL13856857 | 0.75 | TP53 (0.61) | MAPTRXFP1POLBTP53NPSR1 | |
| SCHEMBL12325796 | 0.73 | ALDH1A1 (0.52) | MAPTLMNAPOLBSMN1; SMN2NPSR1 | |
| SCHEMBL6489608 | 0.72 | SMN1; SMN2 (0.51) | LMNASMN1; SMN2NPSR1ALDH1A1HTT | |
| Water SCHEMBL1905420 | 0.71 | SMN1; SMN2 (0.50) | MAPTLMNASMN1; SMN2NPSR1ALDH1A1 | |
| Water SCHEMBL1905418 | 0.71 | SMN1; SMN2 (0.50) | MAPTLMNASMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL3072473 | 0.71 | ALDH1A1 (0.52) | MAPTLMNAPOLBSMN1; SMN2ALPG | |
| SCHEMBL23527195 | 0.68 | ALDH1A1 (0.77) | MAPTLMNAPOLBCDC25ACDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | claimed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | claimed |