SCHEMBL7748818

SCHEMBL7748818

CN(C(=O)CNCc1cccc2ccccc12)[C@@H](CCC(N)=O)C(=O)O

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.44
FOLH1 Q04609 1/20 0.43
ALDH1A1 P00352 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
KDM4E B2RXH2 1/20 0.39
MEN1 O00255 2/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
SLC1A3 P43003 1/20 0.39
SLC1A2 P43004 1/20 0.39
SLC1A1 P43005 1/20 0.39
MAPT P10636 1/20 0.39
METAP2 P50579 1/20 0.39
MMP9 P14780 1/20 0.38
MTNR1A P48039 1/20 0.38
DPP4 P27487 1/20 0.37
POLB P06746 1/20 0.36
CD38 P28907 1/20 0.36
CA2 P00918 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7748820 1.00 KMT2A (0.44) KMT2AFOLH1ALDH1A1TDP1KDM4E
SCHEMBL8307349 0.90 KMT2A (0.40) KMT2AFOLH1ALDH1A1TDP1KDM4E
SCHEMBL7748873 0.77 KMT2A (0.45) KMT2AFOLH1ALDH1A1TDP1KDM4E
SCHEMBL7393110 0.76 KMT2A (0.50) KMT2AALDH1A1TDP1MEN1L3MBTL1
SCHEMBL2245801 0.73 FOLH1 (0.53) KMT2AFOLH1ALDH1A1TDP1KDM4E
SCHEMBL7748888 0.72 KMT2A (0.42) KMT2AFOLH1ALDH1A1TDP1KDM4E
SCHEMBL7748879 0.72 KMT2A (0.42) KMT2AFOLH1ALDH1A1TDP1KDM4E
Hydrochloric Acid SCHEMBL4226418 0.71 KMT2A (0.49) KMT2AFOLH1ALDH1A1TDP1KDM4E
Hydrochloric Acid SCHEMBL4236114 0.70 KMT2A (0.48) KMT2AALDH1A1TDP1KDM4EMEN1
SCHEMBL181325 0.70 TDP1 (0.61) KMT2AFOLH1ALDH1A1TDP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0906099-A4 A METHOD OF TREATING CANCER MERCK & CO INC (US) 2001-02-07 EP claimed
EP-0906099-A1 A METHOD OF TREATING CANCER Merck & Co., Inc. (US) 1999-04-07 EP claimed
WO-1997036587-A1 A METHOD OF TREATING CANCER MERCK & CO., INC. (US) 1997-10-09 WO claimed
EP-0906099-A4 A METHOD OF TREATING CANCER MERCK & CO INC (US) 2001-02-07 EP disclosed
EP-0952842-A2 A METHOD OF TREATING CANCER Merck & Co., Inc. (US) 1999-11-03 EP disclosed
EP-0906099-A1 A METHOD OF TREATING CANCER Merck & Co., Inc. (US) 1999-04-07 EP disclosed
WO-1997038664-A2 A METHOD OF TREATING CANCER MERCK & CO., INC. (US) 1997-10-23 WO disclosed
WO-1997036587-A1 A METHOD OF TREATING CANCER MERCK & CO., INC. (US) 1997-10-09 WO disclosed