Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744266 | 0.89 | KMT2A (0.43) | KMT2AALDH1A1MEN1L3MBTL1FOLH1 | |
| SCHEMBL7748820 | 0.77 | KMT2A (0.44) | KMT2AALDH1A1MEN1L3MBTL1FOLH1 | |
| SCHEMBL7748818 | 0.77 | KMT2A (0.44) | KMT2AALDH1A1MEN1L3MBTL1FOLH1 | |
| SCHEMBL7393110 | 0.72 | KMT2A (0.50) | KMT2AALDH1A1MEN1L3MBTL1TDP1 | |
| SCHEMBL181325 | 0.71 | TDP1 (0.61) | KMT2AALDH1A1MEN1L3MBTL1FOLH1 | |
| SCHEMBL8439130 | 0.70 | FNTA (0.63) | KMT2AALDH1A1MEN1L3MBTL1FOLH1 | |
| SCHEMBL7751346 | 0.70 | FNTA (0.63) | KMT2AALDH1A1MEN1L3MBTL1FOLH1 | |
| SCHEMBL8307349 | 0.69 | KMT2A (0.40) | KMT2AALDH1A1MEN1L3MBTL1FOLH1 | |
| SCHEMBL8308110 | 0.69 | FOLH1 (0.47) | KMT2AALDH1A1MEN1L3MBTL1FOLH1 | |
| SCHEMBL4679636 | 0.68 | ATM (0.55) | KMT2AALDH1A1MEN1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906099-A4 | A METHOD OF TREATING CANCER | MERCK & CO INC (US) | 2001-02-07 | — | — | EP | disclosed |
| EP-0952842-A2 | A METHOD OF TREATING CANCER | Merck & Co., Inc. (US) | 1999-11-03 | — | — | EP | disclosed |
| EP-0906099-A1 | A METHOD OF TREATING CANCER | Merck & Co., Inc. (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997038664-A2 | A METHOD OF TREATING CANCER | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |
| WO-1997036587-A1 | A METHOD OF TREATING CANCER | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |