Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | TNF | P01375 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770917 | 0.84 | ACHE (0.48) | CA12CA1CA2CA9LMNA | |
| SCHEMBL5742697 | 0.83 | ACHE (0.50) | CA12CA1CA2CA9LMNA | |
| SCHEMBL7294570 | 0.82 | ALDH1A1 (0.54) | CA12CA1CA2CA9LMNA | |
| Hydrochloric Acid SCHEMBL5896507 | 0.82 | ACHE (0.49) | CA12CA1CA2CA9LMNA | |
| SCHEMBL1370408 | 0.81 | GAA (0.55) | CA12CA1CA2CA9LMNA | |
| SCHEMBL13580006 | 0.80 | ALDH1A1 (0.50) | CA12CA1CA2CA9LMNA | |
| SCHEMBL17997742 | 0.78 | TSHR (0.50) | LMNAHIF1AALDH1A1PDE4APDE4B | |
| SCHEMBL2990030 | 0.77 | PDE4A (0.51) | CA12CA1CA2CA9LMNA | |
| SCHEMBL2993072 | 0.77 | MAPK1 (0.51) | LMNAHIF1AALDH1A1PDE4APDE4B | |
| SCHEMBL4848590 | 0.76 | SMN1; SMN2 (0.50) | CA1CA2LMNAHIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200987-B1 | ADMINISTERING AS TUMOR NECROSIS FACTOR INHIBITORS; CACHEXIA, ENDOTOXIN SHOCK; RETROVIRUS VIRICIDES | CELGENE CORPORATION | 2001-03-13 | — | — | US | disclosed |