Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL151560 | 0.94 | CYP1A2 (0.57) | PDE10ACYP1A2KDM1AMAOAMAOB | |
| Ethylbenzene SCHEMBL28002148 | 0.89 | CYP1A2 (0.52) | PDE10ACYP1A2KDM1AMAOAMAOB | |
| Quinoline SCHEMBL28313280 | 0.86 | ALDH1A1 (0.57) | PDE10ACYP1A2PDGFRBPDGFRAPOLB | |
| SCHEMBL1094558 | 0.82 | KDM1A (0.54) | PDE10ACYP1A2KDM1AMAOAMAOB | |
| SCHEMBL6115113 | 0.80 | TRPV1 (0.55) | PDE10ACYP1A2KDM1AMAOAMAOB | |
| SCHEMBL1037165 | 0.79 | KDM1A (0.51) | PDE10ACYP1A2KDM1AMAOAMAOB | |
| SCHEMBL3396692 | 0.79 | CYP1A2 (0.55) | PDE10ACYP1A2KDM1AMAOAMAOB | |
| SCHEMBL28357870 | 0.79 | PDE10A (0.44) | PDE10ACYP1A2KDM1AMAOAMAOB | |
| Ammonia Solution, Strong SCHEMBL5507007 | 0.79 | TRPV1 (0.53) | PDE10ACYP1A2KDM1AMAOAMAOB | |
| SCHEMBL6933468 | 0.78 | PDGFRB (0.53) | PDE10ACYP1A2KDM1AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069901-A4 | CALCILYTIC COMPOUNDS AND METHOD OF USE | SMITHKLINE BEECHAM CORP (US) | 2001-06-13 | — | — | EP | claimed |
| EP-1069901-A1 | CALCILYTIC COMPOUNDS AND METHOD OF USE | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-24 | — | — | EP | claimed |
| WO-1999051241-A1 | CALCILYTIC COMPOUNDS AND METHOD OF USE | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-14 | — | — | WO | claimed |