Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21480122 | 0.90 | KMT2A (0.57) | KMT2AMEN1LMNAHSP90AA1HSP90AB1 | |
| SCHEMBL4039962 | 0.86 | KMT2A (0.58) | KMT2AMEN1LMNAHDAC1HDAC2 | |
| SCHEMBL17796920 | 0.84 | ALDH1A1 (0.52) | KMT2AMEN1HDAC2ALDH1A1HPGD | |
| SCHEMBL6073016 | 0.83 | ALDH1A1 (0.56) | KMT2AMEN1LMNAHDAC1HDAC2 | |
| SCHEMBL21480227 | 0.82 | KMT2A (0.50) | KMT2AMEN1LMNAHDAC1HDAC2 | |
| SCHEMBL22606887 | 0.81 | NPC1 (0.56) | KMT2AMEN1LMNAKCNK3KCNK9 | |
| SCHEMBL1504999 | 0.80 | KMT2A (0.46) | KMT2AMEN1LMNAHSP90AA1HSP90AB1 | |
| SCHEMBL16203451 | 0.78 | LMNA (0.77) | KMT2AMEN1LMNAHSP90AA1HSP90AB1 | |
| SCHEMBL9809483 | 0.78 | HDAC1 (0.59) | KMT2AMEN1LMNAHDAC1HDAC2 | |
| SCHEMBL21933933 | 0.76 | LMNA (0.68) | KMT2AMEN1LMNAHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0776322-B1 | METHOD FOR THE PREPARATION OF TAXOL AND ITS DERIVATIVES | PHARMACIA & UPJOHN SPA (IT) | 2001-11-07 | — | — | EP | disclosed |
| EP-1116718-A2 | Method for the preparation of taxol and its derivatives | PHARMACIA & UPJOHN S.p.A. (IT) | 2001-07-18 | — | — | EP | disclosed |
| US-5767282-A | Method for the preparation of taxol and its derivatives | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-06-16 | — | — | US | disclosed |