SCHEMBL7749070

SCHEMBL7749070

CCCc1[nH]c2ccccc2c1CCN

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.68
CHRNA7 P36544 2/20 0.68
CHRNA4 P43681 2/20 0.68
HTR6 P50406 6/20 0.52
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
RAB9A P51151 1/20 0.46
ALDH1A1 P00352 3/20 0.45
HPGD P15428 3/20 0.45
KDM4E B2RXH2 2/20 0.45
CYP1A2 P05177 3/20 0.45
CYP3A4 P08684 3/20 0.45
CYP2D6 P10635 2/20 0.45
MPO P05164 1/20 0.45
CYP2A6 P11509 1/20 0.45
NFKB1 P19838 1/20 0.45
HTR1D P28221 1/20 0.45
HTR1B P28222 1/20 0.45
HTR2A P28223 1/20 0.45
HTR2C P28335 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7089878 0.89 CHRNB2 (0.55) CHRNB2CHRNA7CHRNA4HTR6MEN1
SCHEMBL3886866 0.88 HTR6 (0.63) CHRNB2CHRNA7CHRNA4HTR6MEN1
Hydrochloric Acid SCHEMBL275390 0.87 HTR6 (0.61) CHRNB2CHRNA7CHRNA4HTR6MEN1
Cyanide SCHEMBL28564062 0.86 CHRNB2 (0.52) CHRNB2CHRNA7CHRNA4HTR6MEN1
SCHEMBL20281778 0.86 CHRNB2 (0.71) CHRNB2CHRNA7CHRNA4HTR6MEN1
SCHEMBL9300309 0.83 HTR6 (0.49) CHRNB2CHRNA7CHRNA4HTR6MEN1
SCHEMBL5463620 0.81 CHRNB2 (0.65) CHRNB2CHRNA7CHRNA4HTR6MEN1
SCHEMBL21790166 0.81 CHRNB2 (0.65) CHRNB2CHRNA7CHRNA4HTR6MEN1
SCHEMBL27683744 0.81 HTR6 (0.50) CHRNB2CHRNA7CHRNA4HTR6MEN1
SCHEMBL14193990 0.81 CHRNB2 (0.64) CHRNB2CHRNA7CHRNA4HTR6MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1071664-A1 SUBSTITUTED 2-OXO-ALKANOIC ACID- 2-(INDOL-3-YL)-ETHYL] AMIDES BAYER AG (DE) 2001-01-31 EP disclosed
WO-1999054301-A1 SUBSTITUTED 2-OXO-ALKANOIC ACID-[2-(INDOL-3-YL)-ETHYL] AMIDES BAYER AKTIENGESELLSCHAFT (DE) 1999-10-28 WO disclosed