Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | AGER | Q15109 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | DHODH | Q02127 | 2/20 | 0.47 |
| ▸ | MYC | P01106 | 2/20 | 0.46 |
| ▸ | RORB | Q92753 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9265839 | 0.93 | KDM4E (0.74) | KDM4ETDP1ALDH1A1ALOX15L3MBTL1 | |
| SCHEMBL28618374 | 0.84 | KDM4E (0.61) | KDM4ETDP1ALDH1A1ALOX15L3MBTL1 | |
| SCHEMBL28265636 | 0.83 | KDM4E (0.59) | KDM4ETDP1ALDH1A1ALOX15L3MBTL1 | |
| SCHEMBL26919304 | 0.83 | KDM4E (0.59) | KDM4ETDP1ALDH1A1ALOX15L3MBTL1 | |
| SCHEMBL30555267 | 0.83 | KDM4E (0.59) | KDM4ETDP1ALDH1A1ALOX15L3MBTL1 | |
| SCHEMBL3820615 | 0.83 | KDM4E (0.65) | KDM4ETDP1ALDH1A1ALOX15L3MBTL1 | |
| SCHEMBL6876755 | 0.83 | KDM4E (0.59) | KDM4ETDP1ALDH1A1ALOX15L3MBTL1 | |
| SCHEMBL2555756 | 0.83 | KDM4E (0.65) | KDM4ETDP1ALDH1A1ALOX15L3MBTL1 | |
| SCHEMBL6772447 | 0.81 | RORB (0.58) | KDM4ETDP1LMNASMN1; SMN2RORB | |
| SCHEMBL10969548 | 0.79 | RORB (0.60) | KDM4ETDP1ALDH1A1ALOX15L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214996-B1 | SHOWING EXCELLENT BRONCHIOCONSTRICTION INHIBITORY ACTIVITY,USEFUL IN THE PROPHYLAXIS OR TREATNEBT OF ASTHMA | TANABE SEIYAKU CO., LTD. (JP) | 2001-04-10 | — | — | US | disclosed |
| US-6005106-A | BRONCHOCONSTRICTOR AGENTS USEFUL IN THE TREATMENT OF ASTHMA | TANABE SEIYAKU CO., LTD. (JP) | 1999-12-21 | — | — | US | disclosed |
| US-5969140-A | AMINOPYRIDINE DERIVATIVES OF NAPHTHALENE FOR TREATMENT OF ASTHMA AND BRONCHOCONSTRICTOR INHIBITORS | TANABE SEIYAKU CO., LTD. (JP) | 1999-10-19 | — | — | US | disclosed |
| EP-0748805-B1 | Naphthalene derivatives, process for the preparation thereof, and intermediates therefor, and pharmaceutical compositions comprising them | TANABE SEIYAKU CO (JP) | 1998-04-08 | — | — | EP | disclosed |
| EP-0748805-A1 | Naphthalene derivatives, process for the preparation thereof, and intermediates therefor, and pharmaceutical compositions comprising them | TANABE SEIYAKU CO., LTD. (JP) | 1996-12-18 | — | — | EP | disclosed |