Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.43 |
| ▸ | PELI1 | Q96FA3 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7749404 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2TP53MAPTPOLBNPC1 | |
| SCHEMBL22501856 | 0.87 | MEN1 (0.48) | SMN1; SMN2TP53MAPTPOLBALDH1A1 | |
| SCHEMBL22501857 | 0.87 | MEN1 (0.48) | SMN1; SMN2TP53MAPTPOLBALDH1A1 | |
| SCHEMBL28820634 | 0.79 | EGFR (0.66) | SMN1; SMN2TP53MAPTNPC1RAB9A | |
| SCHEMBL31236185 | 0.77 | ALDH1A1 (0.62) | SMN1; SMN2MAPTPOLBNPC1HPGD | |
| SCHEMBL1801329 | 0.77 | ALDH1A1 (0.62) | SMN1; SMN2MAPTPOLBNPC1HPGD | |
| SCHEMBL31236186 | 0.77 | ALDH1A1 (0.62) | SMN1; SMN2MAPTPOLBNPC1HPGD | |
| SCHEMBL30499697 | 0.73 | KIF11 (0.51) | SMN1; SMN2MAPTNPC1HPGDNFKB1 | |
| SCHEMBL9835752 | 0.73 | NPC1 (0.53) | SMN1; SMN2MAPTNPC1HPGDNFKB1 | |
| SCHEMBL6823604 | 0.73 | KIF11 (0.51) | SMN1; SMN2MAPTNPC1HPGDNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071658-A2 | BTK INHIBITORS AND METHODS FOR THEIR IDENTIFICATION AND USE | Parker Hughes Institute (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999054286-A2 | BTK INHIBITORS AND METHODS FOR THEIR IDENTIFICATION AND USE | PARKER HUGHES INSTITUTE (US) | 1999-10-28 | — | — | WO | disclosed |