Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 19/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CYP11A1 | P05108 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6139175 | 0.82 | CYP19A1 (0.45) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Hydrochloric Acid SCHEMBL7505934 | 0.81 | CYP19A1 (0.44) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| SCHEMBL11847657 | 0.81 | ALDH1A1 (0.54) | CYP19A1 | |
| SCHEMBL11851731 | 0.81 | CYP19A1 (0.54) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| SCHEMBL11843636 | 0.78 | CYP19A1 (0.51) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| SCHEMBL7505925 | 0.72 | CYP19A1 (0.45) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| SCHEMBL6246501 | 0.71 | CYP19A1 (0.52) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| SCHEMBL433244 | 0.70 | SLC6A3 (0.59) | — | |
| SCHEMBL7749347 | 0.69 | CYP19A1 (0.43) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| SCHEMBL23216786 | 0.65 | HDAC6 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888304-B1 | SUBSTITUTED 3-ARYL-3-CARBOXYALKYL GLUTARAMIDES, METHOD FOR PREPARING SAME BY 4-ARYLO-4-CYANOHEPTANE DICARBOXYLIC ACID CYCLISATION, AND USE THEREOF FOR PREPARING 3-ARYL-3-HYDROXYALKYLPIPERIDINES | SANOFI SYNTHELABO (FR) | 2001-10-04 | — | — | EP | disclosed |
| US-6242607-B1 | SUCH AS 4-CYANO-4-(3,4-DICHLOROPHENYL)HEPTANEDIOIC ACID USED AS ANTAGONISTS OF NEUROKININES | SANOFI-SYNTHELABO (FR) | 2001-06-05 | — | — | US | disclosed |
| US-6008360-A | Substituted 3-aryl-3-carboxyalkyl glutaramides, method for preparing same by 4-arylo-4-cyanoheptane dicarboxylic acid cyclisation, and use thereof for preparing 3-aryl-3-hydroxyalkylpiperidines | SANOFI-SYNTHELABO (FR) | 1999-12-28 | — | — | US | disclosed |
| EP-0888304-A1 | SUBSTITUTED 3-ARYL-3-CARBOXYALKYL GLUTARAMIDES, METHOD FOR PREPARING SAME BY 4-ARYLO-4-CYANOHEPTANE DICARBOXYLIC ACID CYCLISATION, AND USE THEREOF FOR PREPARING 3-ARYL-3-HYDROXYALKYLPIPERIDINES | SANOFI (FR) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032852-A1 | SUBSTITUTED 3-ARYL-3-CARBOXYALKYL GLUTARAMIDES, METHOD FOR PREPARING SAME BY 4-ARYLO-4-CYANOHEPTANE DICARBOXYLIC ACID CYCLISATION, AND USE THEREOF FOR PREPARING 3-ARYL-3-HYDROXYALKYLPIPERIDINES | SANOFI (FR) | 1997-09-12 | — | — | WO | disclosed |