Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.59 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.59 |
| ▸ | MMP13 | P45452 | 3/20 | 0.59 |
| ▸ | MMP1 | P03956 | 3/20 | 0.59 |
| ▸ | MMP14 | P50281 | 2/20 | 0.59 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.59 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.59 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.58 |
| ▸ | TARS1 | P26639 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 2/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | PGR | P06401 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | MMP7 | P09237 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16540405 | 0.88 | EGFR (0.60) | MMP2MMP13MMP1MEP1BMMP9 | |
| SCHEMBL386093 | 0.85 | KDM4E (0.57) | MMP2MMP13MMP1MMP9EGFR | |
| SCHEMBL15625452 | 0.83 | BCL2L1 (0.62) | MMP2ADAMTS4MMP13MMP1MMP14 | |
| SCHEMBL8229504 | 0.83 | EGFR (0.65) | MMP2MMP13MMP1MEP1BMMP9 | |
| SCHEMBL17286576 | 0.79 | TARS1 (0.73) | MMP2ADAMTS4MMP13MMP1MMP14 | |
| SCHEMBL17943672 | 0.79 | BCL2L1 (0.58) | MMP2ADAMTS4MMP13MMP1MMP14 | |
| SCHEMBL21967031 | 0.78 | MMP2 (0.51) | MMP2ADAMTS4MMP13MMP1MMP14 | |
| SCHEMBL3092148 | 0.77 | MCL1 (0.53) | MMP2ADAMTS4MMP13MMP1MMP14 | |
| SCHEMBL7969578 | 0.77 | EGFR (0.60) | MMP2MMP13MMP1MMP9EGFR | |
| SCHEMBL24992267 | 0.77 | TARS1 (0.70) | MMP2ADAMTS4MMP13MMP1MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10844032-B2 | Substituted benzofuran, benzothiophene and indole Mcl-1 inhibitors | VANDERBILT UNIVERSITY (US) | 2020-11-24 | — | — | US | disclosed |
| EP-3038618-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | Vanderbilt University (US) | 2016-07-06 | — | — | EP | disclosed |
| WO-2015031608-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY (US) | 2015-03-05 | — | — | WO | disclosed |
| EP-0984959-A4 | AROMATIC SULFONYL ALPHA-HYDROXY HYDROXAMIC ACID COMPOUNDS | MONSANTO CO (US) | 2001-05-02 | — | — | EP | disclosed |
| EP-0984959-A1 | AROMATIC SULFONYL ALPHA-HYDROXY HYDROXAMIC ACID COMPOUNDS | MONSANTO COMPANY (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998039326-A1 | AROMATIC SULFONYL ALPHA-HYDROXY HYDROXAMIC ACID COMPOUNDS | MONSANTO COMPANY (US) | 1998-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10844032-B2 | Substituted benzofuran, benzothiophene and indole Mcl-1 inhibitors | MCL1, BCL2L1, BCLAF1 | MMP2 4296/4885ADAMTS4 4236/4885MMP13 4137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.